During an approximately 10 mile run, do 6 x 6 minutes at threshold effort (3 word effort or the level of effort you could sustain for an hour in a race) with 2 minutes jog recovery. Probably best to do this on a hilly course such that you reach threshold effort levels without having to hang on to a fast pace with the extra cumulative impact and muscle damage that brings.
Remember that these sessions are training your physiological systems to respond to work load. It doesn't matter if that load is generated running slower up hills or faster on the flat.
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